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In the appointment of high-dose, long-term use and individual features of the selectivity may decrease the body. If ingestion is well absorbed from the gastrointestinal tract. Simultaneous food intake does not affect absorption. Repeated ingestion of doses 7,5 — 15 mg, plasma concentrations are proportional to dose. The equilibrium concentrations are reached within 3 — 5 days. Plasma protein binding mostly to albumin is about 99. The value associated with protein fractions do not depend on the concentration in the therapeutic dose range.
The volume of distribution of meloxicam in average 10 liters. It penetrates through the blood-tissue barriers. Almost completely metabolized in the liver with the formation of four pharmacologically inactive derivatives. Studies in vitro showed that the metabolic conversion of the important role played by CYP2C9. Derived equally from feces and urine, mainly as metabolites.
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Application of the substance Meloxicam Inflammatory and degenerative diseases of the joints accompanied by pain: Restrictions on the use Erosive — ulcerative lesions of the gastrointestinal tract in the history of elderly patients. Application of pregnancy and breastfeeding Teratogenic effects. Meloxicam passes through the placental barrier. Adequate and well-controlled studies in pregnant women have not performed. Pregnancy is possible if the expected effect of therapy outweighs the potential risk to the fetus. The use of meloxicam in the III trimester of pregnancy, should be deleted.
In studies in rats demonstrated that meloxicam, as well as other agents that inhibit the synthesis of GHGs. The effects of meloxicam on labor and delivery in humans is unknown. Category effects on the fetus by FDA ; C. It can affect fertility, so it is not recommended for women wishing to become pregnant.
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A higher risk of serious complications from the gastrointestinal tract are elderly patients, the probability of occurrence of these complications increases as long-term use.
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